Defining the factors that contribute to tumor growth, vascularization and metastasis may facilitate better diagnosis of primary tumors and may lead to the development of novel cancer therapeutics.
(1)Asdirect actions, selective toxic action that attacks only cancer cells without damaging normal cells, apoptosis-inducing action, neovascularization inhibitory action, and metastasis infiltration inhibitory action are reported.
Poor wound healing after trauma, surgery, acute illness, or chronic disease conditions affects millions of people worldwide each year and is the consequence of poorly regulated elements of the healthy tissue repair response, including inflammation, angiogenesis, matrix deposition, and cell recruitment.
I couldn't tell you about this today, but a good example is the research for developing noninvasive angiogenic therapy using sound waves(shock wave and ultrasound wave), on which I have been working for more than 15 years.
Meaning that there were these pinpoint tumors in skeletal muscle, but only .16 percent of actual metastases-- suggesting that maybe skeletal muscle is able to control the angiogenesis, is able to control the tumors recruiting these blood vessels.
We believe that synthesis of integrin inhibitors with the use of sequence information and comprehensive investigation of the effects of individual integrins will allow efficient development of effective angiogenesis inhibitors and would like to conduct joint research to achieve the goal.
Further, as part of its basic policy for conducting translational research where the results from fundamental research are transformed into clinical applications, the Department is developing noninvasive angiogenesis therapy using external shock waves(currently in clinical trial) and molecular-targeted therapy for pulmonary hypertension currently in preparation.
Furthermore, researchers at Harvard University, the University of Cincinnati, and Tokyo Institute of Technology reported that inhibition of all periostins suppressed cardiac failure after AMI, but periostin2 and periostin4 had cardioprotective effects such as myocardial regeneration, angiogenesis, and protection of cardiac rupture after AMI.
English
中文
عربى
Български
বাংলা
Český
Dansk
Deutsch
Ελληνικά
Español
Suomi
Français
עִברִית
हिंदी
Hrvatski
Magyar
Bahasa indonesia
Italiano
Қазақ
한국어
മലയാളം
मराठी
Bahasa malay
Nederlands
Norsk
Polski
Português
Română
Русский
Slovenský
Slovenski
Српски
Svenska
தமிழ்
తెలుగు
ไทย
Tagalog
Turkce
Українська
اردو
Tiếng việt