Real-world data on afatinib and feasibility in elderly patientsThe irreversible ErbB family inhibitor afatinib is approved in several countries worldwide for the treatment of patients with EGFR-mutant NSCLC.
The risk of breast cancer recurrence in these women was similar to the risk in women who either did not use a CYP2D6 inhibitor or who used a CYP2D6 inhibitor for less than 60 days.
Preliminary test results provided by the WHO Collaborating Centre in China suggest that the virus is susceptible to the neuraminidase inhibitors(oseltamivir and zanamivir).
However, many patients are not suitable candidates for or are unwilling to receive vitamin K antagonist therapy, and these patients have a high risk of stroke.
In order to clarify the role of microglia during brain development, using inhibitory drugs and genetically-engineered mice in order to suppress microglia activity, this group succeeded in observing brain activity and development.
Other proteasome inhibitor drugs have also been developed, therefore further research should focus on whether these newer drugs provide additional benefits and fewer side effects than bortezomib.
In a phase II trial of cediranib, an inhibitor of all three known vascular epidermal growth factor receptors, 15 of 43 adult patients(35%) with metastatic alveolar soft part sarcoma had partial responses.
Contrasting results when comparing SGLT2 inhibitor initiators to DPP-4 inhibitor and SU initiators highlight the importance of choosing appropriate comparator drugs when addressing comparative effectiveness and safety questions that can inform clinical decision-making.
ALK-positive disease: pushing the borders of treatability- memoinoncology CNS and non-CNS efficacy of alectinib confirmed in ALEXStandard treatment for patients with ALK-positive, advanced NSCLC includes the first-generation ALK inhibitor crizotinib and, more recently, second-generation ALK TKIs such as ceritinib and alectinib.
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