英語 での Heavy chain の使用例とその 日本語 への翻訳
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There are several different types of antibody heavy chain, and several different kinds of antibodies, which are grouped into different isotypes based on which heavy chain they possess.
いくつかの異なる型の抗体重鎖、およびいくつかの異なる種類の抗体が存在し、それらがどの重鎖を有するかに基づいて異なるアイソタイプに分類される。The heavy chain constant region is comprised of three domains, CH1, CH2
Theheavychainconstantregiontypicallyiscomprisedofthreedomains,Although the boundaries of the Fc region may vary, the human IgG heavy chain Fc region is usually defined to include residues E216 or C226 or P230 to its carboxyl-terminus, wherein the numbering is according to the EU index as in Kabat.
interact with the CDRs, it is preferred not to consider the last 8 amino acids of heavy chain CDR 2 as part of the CDRs, because from the viewpoint of structure, these 8 amino acids behave more as part of the framework.
itispreferablethatthelast8aminoacidsofheavychainCDRnotconsideredpartoftheCDR.なぜなら、構造の観点から、これらの８アミノ酸は、フレームワークとして振舞うからである。In one aspect, such a fragment will retain at least one CDR present in the full-length light or heavy chain, and in some embodiments will comprise a single heavy chain and/or light chain or portion thereof.
一態様において，このような断片は，完全長の軽鎖又は重鎖中に存在する少なくとも1つのCDRを保持し，幾つかの実施形態において，単一の重鎖及び/又は軽鎖又はその一部を含む。In the light and heavy chains, the variable and constant regions are conjugated by a“J” region of about 12 or more amino acids, and the heavy chain also includes a“D” region of more than about 10 amino acids.
完全長の軽鎖及び重鎖内に、典型的には、可変及び定常領域は、約１２又はそれ以上のアミノ酸の「Ｊ」領域によって連結されており、重鎖は約１０以上のアミノ酸の「Ｄ」領域も含む。as used herein, refers to a population of antibody molecules that contain only one molecular species of antibody molecule consisting of a unique light chain gene product and a unique heavy chain gene product, hi particular, the complementarity determining regions(CDRs) of the monoclonal antibody are identical in all the molecules of the population.
containonlyonemolecularspeciesofantibodymoleculeconsistingofauniquelightMake some heavy chains.
重い鎖をちょうだい。It's like a slave requesting heavier chains.
まるで重い鎖の足枷を引きずっている奴隷のようである。Depending on the amino acid sequences of the constant domains of their heavy chains, antibodies(immunoglobulins) can be assigned to different classes.
その重鎖の定常ドメインのアミノ酸配列に基づいて、抗体(免疫グロブリン)は異なるクラスが割り当てられる。The CDRs of the light and heavy chains are primarily responsible for the interaction of the antibody with the antigen.
軽鎖及び重鎖のCDRは、主に、抗体の抗原との相互作用を担っている。The sequences of the framework regions of different light or heavy chains are relatively conserved within a species.
異なる軽鎖または重鎖のフレームワーク領域の配列は、種内で比較的保存されている。Both upper parts of the two heavy chains are entangled with two light chains. .
上の部分の左右の重い鎖にからまって二本の軽い鎖があります。Whenever the ferry arrived, his wrinkled tough hands manipulated the lever to move heavy chains which suspended the bridge.
船が着く度に彼の皺だらけの無骨な手がレバーを操作してブリッジの重厚な鎖を動かす。Happy thinking that will reap many ransom to release him, they tried to tie with heavy chains, but to accomplish· with a slight movement of the God was shaking over it.
彼を解放した多くの身代金を得るだろう幸せなことを考える,彼らは重鎖と結ぶしよう,しかし、達成するために·神のわずかな動きでそれ以上に震えていた。The number of cysteine residues in the hinge region of CHI is altered to, for example, facilitate assembly of the light and heavy chains or to increase or decrease the stability of the antibody.
ＣＨ１のヒンジ領域内のシステイン残基の数は、例えば、軽鎖および重鎖の集合を促進させるために、または抗体の安定性を増強もしくは低減するために改変される。This definition of human antibodies includes an antibody that contains at least one polypeptide heavy chains of a human or at least one polypeptide light chain of a human.
ヒト化抗体のこの定義は、少なくとも１つのヒト重鎖ポリペプチドあるいは少なくとも１つのヒト軽鎖ポリペプチドを含む抗体を含んでいる。A“F(ab′)2 fragment” thus is composed of two Fab′ fragments that are held together by a disulfide bond between the two heavy chains.
従って、Ｆ（ａｂ'）２断片は、２つの重鎖間のジスルフィド結合によって一緒に固定された２つのＦａｂ'断片から構成される。Cytoplasmic dynein 1 heavy chain 1.
細胞質ダイニン1重鎖1。Only the heavy chain is shown.
