Examples of using Aprepitant in English and their translations into Croatian
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Colloquial
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Ecclesiastic
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Computer
Concomitant treatment with moderate CYP3A4 inhibitors(e.g. aprepitant, erythromycin, fluconazole,
amprenavir, aprepitant, diltiazem, fluconazole,
erythromycin, aprepitant, amiodarone) should only be administered with caution in patients receiving 25 mg
including amprenavir, aprepitant, diltiazem, fluconazole,
The benefit of aprepitant combination therapy in the full study population was mainly driven by the results observed in patients with poor control with the standard regimen such as in women,
100 mg dose of[14C]-fosaprepitant, a prodrug for aprepitant, indicating a substantial presence of metabolites in the plasma.
The most common adverse reactions reported at a greater incidence in paediatric patients treated with the aprepitant regimen than with the control regimen while receiving emetogenic cancer chemotherapy were hiccups(3.3% versus 0.0%)
clarithromycin(for bacterial infections), aprepitant(to prevent nausea
highly emetogenic chemotherapy, the aprepitant regimen was compared to a control regimen for the prevention of CINV.
consisted of placebo for aprepitant on Days 1, 2 and 3 in combination with ondansetron on Day 1.
fosaprepitant 150 mg(N=1,147) was compared with a 3-day aprepitant regimen(N=1,175) in adult patients receiving a HEC regimen that included cisplatin≥ 70 mg/m2.
Aprepitant powder is used with other medications in adults
Following a single 165 mg aprepitant dose, a transient moderate increase for two days possibly followed by a mild decrease in exposure of immunosuppressants metabolised by CYP3A4(e.g., cyclosporine, tacrolimus,
Interaction studies with aprepitant 165 mg and midazolam have not been conducted; however, the following study with 200 mg of aprepitant should be considered when using EMEND 165 mg with medicinal products metabolised via CYP3A4.
Methylprednisolone: Interaction studies with aprepitant 165 mg and methylprednisolone have not been conducted;
use of dexamethasone for antiemetic prophylaxis, and emetogenicity of chemotherapy, the aprepitant regimen provided better control than the control regimen with respect to the complete response endpoints.
Due to modest decreases in protein binding of aprepitant in patients with renal disease, the AUC of pharmacologically active unbound aprepitant was not significantly affected in patients with renal impairment compared with healthy subjects.
are limited since systemic exposures to fosaprepitant and aprepitant were only similar
fosaprepitant Cmax and aprepitant AUC values were up to 3 times and 40 times, respectively, higher than clinical values.
Methylprednisolone: Although the concomitant administration of methylprednisolone with the single 40 mg dose of aprepitant has not been studied, a single 40 mg dose of aprepitant produces a weak inhibition of CYP3A4