Examples of using Are substrates in English and their translations into Polish
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Medicine
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Colloquial
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Official
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Ecclesiastic
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Ecclesiastic
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Financial
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Official/political
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Programming
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Computer
In vitro studies have determined that neither tenofovir disoproxil fumarate nor tenofovir are substrates for the CYP450 enzymes.
However, in vitro studies indicated that clinical drug-drug interactions are unlikely to occur as a result of crizotinib-mediated inhibition of the metabolism of drugs that are substrates for UGT1A4, UGT1A6, or UGT1A9.
In vitro studies in human hepatocytes indicated that clinical drug-drug interactions are unlikely to occur as a result of crizotinib-mediated induction of the metabolism of medicinal products that are substrates for CYP1A2.
In vitro studies indicated that clinical drug-drug interactions are unlikely to occur as a result of crizotinib-mediated inhibition of the metabolism of medicinal products that are substrates for CYP1A2, CYP2C8,
particularly those that are substrates/inhibitors of CYP3A4 e.g. diltiazem,
For other compounds that are substrates for CYP3A(e. g., calcium channel blockers including bepridil,
which are absorbed in the intestines, being substrates for metabolic reactions in the body.
other anticonvulsants that are substrates of CYP isozymes.
Compounds that are substrates of these enzymes may have decreased plasma concentrations when co-administered with efavirenz.
Compounds that are substrates of these enzymes may have decreased plasma concentrations when co-administered with efavirenz.
Lamivudine-TP and carbovir-TP(the active triphosphate form of abacavir) are substrates for and competitive inhibitors of HIV reverse transcriptase RT.
The inhibition of glucuronidation may cause interactions with medicinal products which are substrates of UGT1A1 and exclusively cleared by this pathway.
Agenerase must not be administered concurrently with medicinal products with narrow therapeutic windows that are substrates of cytochrome P450 3A4 CYP3A4.
Caution is advised if Zydelig is used together with narrow therapeutic index drugs that are substrates of these enzymes warfarin, phenytoin, S-mephenytoin.
Therefore, crizotinib may have the potential to increase plasma concentrations of coadministered drugs that are substrates of OCT1 or OCT2 see section 4.5.
Caution is required when Fampyra is prescribed concurrently with medicinal products that are substrates of OCT2 for example, carvedilol, propanolol and metformin.
Coadministration of lapatinib with medicinal product with narrow therapeutic windows that are substrates of CYP3A4 or CYP2C8 should be avoided see section 4.5.
Based on these data, raltegravir is not expected to affect the pharmacokinetics of medicinal products that are substrates of these enzymes or P-glycoprotein.
Frequent monitoring for adverse reactions and toxicity related to antiretroviral agents that are substrates of CYP3A4 is recommended during co- administration with posaconazole.
Agenerase must not be administered concurrently with medicinal products with narrow therapeutic windows containing active substances that are substrates of cytochrome P450 3A4 CYP3A4.