Examples of using Toremifene in English and their translations into Dutch
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Medicine
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Colloquial
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Official
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Ecclesiastic
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Financial
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Computer
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Ecclesiastic
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Official/political
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Programming
Pre-existing endometrial hyperplasia and severe hepatic failure are contra-indications in long- term use of toremifene.
Endometrial hypertrophy may develop during the treatment due to the partial estrogenic effect of toremifene.
It is bound to plasma proteins even more extensively than toremifene, the protein bound fraction being> 99.9.
The elimination of toremifene and its metabolites was significantly increased in patients with activated liver function
In post-menopausal breast cancer patients, toremifene treatment is associated with modest reductions in both total serum cholesterol and low density lipoprotein LDL.
The active substance is toremifene; each tablet contains 60 mg as citrate.
Toremifene treatment has been associated with changes in liver enzyme levels(increases of transaminases) and in very rare occasions with more severe liver function abnormalities jaundice.
where toremifene acts mainly as an anti-estrogen.
Hypercalcemia may occur at the beginning of toremifene treatment in patients with bone metastasis
Licensed in the United States under the brand name Fareston, toremifene citrate is FDA-approved for use in advanced(metastatic) breast cancer.
With these receptors occupied by Toremifene, real Estrogen cannot perform their jobs there.
Fareston(toremifene citrate) is a Selective Estrogen Receptor Modulator(SERM) derived from triphenylethelyne.
Toremifene is also agonistic to Estrogen receptors in other tissues in the body within the liver in particular.
As a layman explanation, Toremifene pretends to be a‘fake' Estrogen that occupies Estrogen receptors within breast tissue.
A few cases of hypercalcaemia have been reported in patients with bone metastases at the beginning of toremifene treatment.
Although they have theoretically interesting hormonal effects, their concentrations during toremifene treatment are too low to have any major biological importance.
in vivo studies have evidenced the potential of toremifene and its metabolite to prolong cardiac repolarisation
Clinicians should be aware that the recovery of the T4/T1 ratio to 0.9 could therefore be delayed in patients who have received toremifene on the same day of the operation.
such as tamoxifen, toremifene, bazedoxifene and raloxifene,
Action potential studies in isolated rabbit heart have shown that toremifene induce cardiac electrophysiological changes which start to develop at concentrations approximately 10 fold compared to the calculated free therapeutic plasma concentration in human.