While toxicity of the liver is uncommon, a person's individual metabolic functions and overall health condition can have an influence over hepatotoxicity.
Local and systemic toxicity is common, especially following long continuous use on large areas of damaged skin, in flexures or with polythene occlusion.
When taking anything that includes clenbuterol, liver toxicity is always a concern, especially when stacked with other drugs such as antibiotics or certain anabolic steroids.
However, the relative efficacy or toxicity of pemetrexed-cisplatin versus pemetrexed-carboplatin has not been established beyond what is generally thought about cisplatin or carboplatin doublet drug therapy.
Bevacizumab-associated toxicities such as hypertension and proteinuria were more prominent than in the first-line trials, but feared safety issues such as gastrointestinal perforations did not occur during the study.
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