Eksempler på bruk av Tolerated dose på Engelsk og deres oversettelse til Norsk
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Nateglinide is indicated for combination therapy with metformin in type 2 diabetic patients inadequately controlled despite a maximally tolerated dose of metformin alone.
female rats up to the maximum tolerated dose revealed no significant impact on fertility.
administer the maximum tolerated dose of IntronA(4 to 5 million IU/m2 daily) to maintain haematological remission.
exaggerated pharmacologic effects of zonisamide at the maximum tolerated dose.
decreased once patients established the maximum tolerated dose of lomitapide.
exercise in adult patients inadequately controlled on their maximal tolerated dose of metformin and pioglitazone.
Metformin(immediate- or extended-release formulations)≥ 1500 mg/day plus maximum tolerated dose, which must be at least half maximum dose,
These effects were seen at a maternally tolerated dose of 20 mg/kg where exposure was equivalent to the human exposure at the recommended dose of 80 mg daily(based on total AUC).
the maximum tolerated dose(MTD) was established at 2.0 mg/m2day with G-CSF
When the maximum tolerated dose is not reached transient myelotoxicity usually occurs in less than 10% of patients, while under the maximum tolerated dose more than 50% can experience reversible bone marrow suppression.
For patients inadequately controlled on dual combination therapy with insulin and the maximal tolerated dose of metformin The dose should provide sitagliptin dosed as 50 mg twice daily(100 mg total daily dose)
In addition, in a 26 week carcinogenicity study using the heterozygous p53(+/-) mouse model, ribavirin did not produce tumours at the maximally tolerated dose of 300 mg/kg plasma exposure factor approximately 2.5 compared to human exposure.
irregular oestrous cycles were observed at the maximum tolerated dose(30 mg/kg)
rats at the maximum tolerated dose, although the exposure to rivastigmine
Patients were titrated over four weeks to a target dose of 8 mg per day or the highest tolerated dose and treated for an additional 13 weeks on the last dose level achieved at the end of the titration period.
not at their pre-defined target LDL-C on a maximally tolerated dose of statin, with or without other lipid-modifying therapy.
The majority of patients in the phase 3 program were taking background lipid-modifying therapy consisting of a maximally tolerated dose of statin, with or without other lipid- modifying therapies, and were at high or very high cardiovascular(CV) risk.
In a phase I dose escalation study in NSCLC patients who were current smokers, pharmacokinetic analyses at steady-state indicated a dose proportional increase in erlotinib exposure when the Tarceva dose was increased from 150 mg to the maximum tolerated dose of 300 mg.
was close to the maximum tolerated dose for mice but not for rats.
exercise plus maximal tolerated dose of a sulphonylurea alone do not provide adequate glycaemic control
