DAPTOMYCIN in Croatian translation

• daptomicin

Examples of using Daptomycin in English and their translations into Croatian

It is recommended that the decision to use daptomycin should take into account the antibacterial susceptibility of the organism and should be based on expert advice.
Pri donošenju odluke o korištenju daptomicina preporučuje se uzeti u obzir antibakterijsku osjetljivost mikroorganizma, a odluka se mora temeljiti na savjetu stručnjaka.

Slowly remove the reconstituted liquid(50 mg daptomycin/ml) from the vial using a sterile needle that is 21 gauge or smaller in diameter.
Polako izvucite rekonstituiranu tekućinu(50 mg daptomicina/ml) iz bočice pomoću sterilne igle promjera 21 G ili manjeg.

Therefore, caution is advised when daptomycin is co- administered with any other medicinal product known to reduce renal filtration.
Stoga se savjetuje oprez pri istodobnoj primjeni daptomicina s bilo kojim lijekom za koji je poznato da smanjuje bubrežnu filtraciju.

aztreonam, daptomycin, levofloxacin, linezolid,
aztreonama, daptomicina, levofloksacina, linezolida,

It cannot be ruled out that those patients with CPK greater than 5 times upper limit of normal at baseline may be at increased risk of further increases during daptomycin therapy.
U bolesnika s početnom vrijednošću CPK 5 puta višom od gornje granice normale ne može se isključiti povećan rizik od daljnjih porasta tijekom terapije daptomicinom.

Severe renal impairment may in itself also pre-dispose to elevations in daptomycin levels which may increase the risk of development of myopathy see above.
Teško oštećenje bubrega može samo po sebi stvoriti sklonost k porastima razina daptomicina, čime se može povećati rizik od razvoja miopatije vidjeti iznad.

There is no clinical experience in patients with the administration of daptomycin as an injection over 2 minutes.
Ne postoji kliničko iskustvo u bolesnika s primjenom daptomicina putem injekcije tijekom 2 minute.

Daptomycin is slowly cleared from the body by haemodialysis(approximately 15% of the administered dose is removed over 4 hours)
Daptomicin se iz tijela sporo uklanja hemodijalizom(otprilike 15% primijenjene doze ukloni se tijekom 4 sata) ili peritonejskom dijalizom otprilike

In vitro studies with human hepatocytes indicate that daptomycin does not inhibit or induce the activities of the following human cytochrome P450 isoforms:
In vitro ispitivanja na ljudskim hepatocitima pokazala su da daptomicin ne inhibira niti inducira aktivnost sljedećih izoenzima ljudskog sustava citokroma P450:

Daptomycin pharmacokinetics are generally linear
Farmakokinetika daptomicina općenito je linearna

Relative to non-obese subjects daptomycin systemic exposure measured by AUC was about 28% higher in moderately obese subjects(Body Mass Index of 25-40 kg/m2)
U usporedbi s ispitanicima koji nisu bili pretili, sustavna izloženost daptomicinu, mjerena pomoću AUC, bila je za oko 28% veća u umjereno pretilih ispitanika(indeks tjelesne mase 25-40 kg/m2)

some in vivo studies designed to investigate the mechanism of daptomycin myotoxicity indicate that the plasma membrane of differentiated spontaneously contracting muscle cells is the target of toxicity.
nekih in vivo ispitivanja kojima se istraživao mehanizam miotoksičnosti daptomicina pokazuju da je cilj toksičnog djelovanja plazmatska membrana diferenciranih mišićnih stanica koje se spontano kontrahiraju.

The overall therapeutic response rate also was similar for the daptomycin and SOC treatment arms for infections caused by MRSA,
Stopa ukupnog terapijskog odgovora bila je slična i za skupine liječene daptomicinom i standardnom skrbi za infekcije uzrokovane MRSA-om,

Following administration of a single 4 mg/kg or 6 mg/kg intravenous dose of daptomycin over a 30- minute period to subjects with various degrees of renal impairment, total daptomycin clearance(CL) decreased
Nakon primjene jednokratne intravenske doze daptomicina od 4 mg/kg ili 6 mg/kg tijekom 30 minuta ispitanicima s različitim stupnjevima oštećenja bubrega, ukupni klirens daptomicina(CL) se smanjivao,

In neonatal dogs, daptomycin caused marked clinical signs of twitching, muscle rigidity in the limbs,
U novorođenih pasa daptomicin je uzrokovao naglašene kliničke znakove trzanja mišića,

Based on pharmacokinetic data and modelling, the daptomycin AUC during the first day after administration of a 6 mg/kg dose to patients on HD
Temeljem farmakokinetičkih podataka i modela, tijekom prvog dana nakon primjene daptomicina u dozi od 6 mg/kg bolesnicima na hemodijalizi ili kontinuiranoj ambulantnoj peritonejskoj dijalizi,

Following the administration of multiple doses, daptomycin AUC0-tau were 387, 438, 439 and 466 µg×hr/ml for 12-17 years,
Nakon primjene višestrukih doza, AUC0-tau daptomicina bila je 387 µg×sat/ml u skupini 12-17 godina,

The active substance is daptomycin.
Djelatna tvar je daptomicin.

It contains the active substance daptomycin.
Sadrži djelatnu tvar daptomicin.

Daptomycin is eliminated primarily by the kidney.
Daptomicin se prvenstveno eliminira bubrezima.