Examples of using Glucuronidation in English and their translations into Finnish
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Medicine
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Computer
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Glucuronidation is the major metabolic pathway for both eslicarbazepine
As a mild inducer of CYP2C9, CYP3A4 and glucuronidation, aprepitant can decrease plasma concentrations of substrates eliminated by these routes.
induce lamotrigine glucuronidation are added.
4-hydroxyospemifene inhibited glucuronidation mainly via UGT1A3 and UGT1A9 at clinically relevant concentrations.
Direct glucuronidation(mediated by UGT1A4) and cytochrome P450(primarily CYP1A2,
Based on a human study with radiolabelled eltrombopag, glucuronidation plays a minor role in the metabolism of eltrombopag.
primidone) which induce hepatic drug-metabolising enzymes induce the glucuronidation of lamotrigine and enhance the metabolism of lamotrigine.
Interaction with indinavir/ ritonavir not studied Morphine levels may be decreased due to induction of glucuronidation by coadministered ritonavir.
Clinically significant drug interactions involving glucuronidation are not anticipated due to limited contribution of individual UGT enzymes in the glucuronidation of eltrombopag.
Oxidation by CYP3A and glucuronidation by UGT2B7 appear to be the major pathways of cobimetinib metabolism.
a transient mild induction of CYP3A4 and glucuronidation.
Interaction with indinavir/ ritonavir not studied Ritonavir induces oxidation by CYP2C9 and glucuronidation and as a result is expected to decrease the plasma concentrations of anticonvulsants.
In vitro studies suggest glucuronidation as a metabolic pathway,
Inhibition of UGT1A3, UGT2B7, UGT1A1, or UGT1A8 may potentially affect the glucuronidation of ospemifene and/or 4-hydroxyospemifene.
Sulfate or glucuronide conjugates were not detected in the human faecal samples, suggesting that sulfation and glucuronidation do not appear to be major pathways involved in the excretion of temsirolimus.
a transient mild induction of CYP3A4 and glucuronidation.
Medicinal products that inhibit glucuronidation, such as NSAIDs
The prominent pathway involves direct glucuronidation, with O-demethylation followed by glucuronide conjugation being a further metabolic pathway.
with subsequent phase II reactions of sulphation and glucuronidation.
valproic acid are metabolised by glucuronidation, possibly resulting in competitive inhibition.