Examples of using Glucuronidation in English and their translations into Italian
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Interaction with indinavir/ ritonavir not studied Ritonavir induces oxidation by CYP2C9 and glucuronidation and as a result is expected to decrease the plasma concentrations of anticonvulsants.
In vitro, ospemifene and 4-hydroxyospemifene inhibited glucuronidation via UGT1A3 and UGT1A9 at clinically relevant concentrations.
In vitro data suggest that the primary route of metabolism of empagliflozin in humans is glucuronidation by uridine 5'-diphosphoglucuronosyltransferases UGT1A3,
UGT1A8 may potentially affect the glucuronidation of ospemifene and/or 4-hydroxyospemifene.
Lamotrigine: Combined hormonal contraceptives have been shown to significantly decrease plasma concentrations of lamotrigine when coadministered likely due to induction of lamotrigine glucuronidation.
valproic acid are metabolised by glucuronidation, possibly resulting in competitive inhibition.
As a mild inducer of CYP2C9, CYP3A4 and glucuronidation, aprepitant can decrease plasma concentrations of substrates eliminated by these routes.
UGT1A3 are responsible for glucuronidation, and bacteria in the lower gastrointestinal tract may be responsible for the cleavage pathway.
Patients with deficient glucuronidation of bilirubin, such as those with Gilbert's syndrome,
Kaletra induces glucuronidation, therefore Kaletra has the potential to reduce zidovudine and abacavir plasma concentrations.
Glucuronidation and renal excretion are the main mechanisms of elimination in CYP2D6 poor metabolisers.
Glucuronidation is the major metabolic pathway for both eslicarbazepine and lamotrigine and therefore an interaction could be expected.
Posaconazole is metabolised via UDP glucuronidation(phase 2 enzymes)
Clinically significant drug interactions involving glucuronidation are not anticipated due to limited contribution of individual UGT enzymes in the glucuronidation of eltrombopag.
In vitro studies suggested that the primary route of metabolism of empagliflozin in humans is glucuronidation by the uridine 5'-diphospho-glucuronosyltransferases UGT2B7,
In vitro, ospemifene and 4-hydroxyospemifene inhibited glucuronidation mainly via UGT1A3 and UGT1A9 at clinically relevant concentrations.
Inhibition of the efflux transported BCRP and glucuronidation isozyme UGT2B7 by netupitant
Your doctor must treat you with caution if you have a glucuronidation disorder like Gilbert's syndrome.
Direct glucuronidation(mediated by UGT1A4) and cytochrome P450(primarily CYP1A2,
The elimination of ataluren is likely dependent on hepatic and intestinal glucuronidation of ataluren followed by renal excretion of the resulting glucuronide metabolite.