Examples of using Hydroxycarbamide in English and their translations into Norwegian
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Ecclesiastic
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Ecclesiastic
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Women of childbearing age receiving hydroxycarbamide should be advised to avoid becoming pregnant, and to inform the treating physician immediately should this occur.
The active substance of Siklos, i.e. hydroxycarbamide, is a substance which inhibits growth
Hydroxycarbamide distributes rapidly throughout the human body,
In addition hydroxycarbamide causes an immediate inhibition of DNA synthesis by acting as a ribonucleotide reductase inhibitor, without interfering with the synthesis of ribonucleic acid or protein.
In patients with Sickle Cell Syndrome hydroxycarbamide was eliminated with a half-life of approximately six to seven hours,
In nearly all clinical studies conducted in Sickle Cell Syndrome, hydroxycarbamide reduced the frequency of vaso-occlusive episodes by 66% to 80%, in children and in adults.
severe peripheral neuropathy have been reported in HIV-infected patients who received hydroxycarbamide in combination with antiretroviral medicinal products,
Hydroxycarbamide crosses the placenta barrier
Hydroxycarbamide administered to male rats at 60 mg/kg b.w./day(about double the recommended usual maximum dose in humans)
Recently, hydroxycarbamide has shown to be associated with the generation of nitric oxide suggesting that nitric oxide stimulates cyclic guanosine monophosphatase(cGMP)
In the event a patient does still not respond when treated with the maximum dose of hydroxycarbamide(35 mg/kg b.w./day)
if the daily dose of hydroxycarbamide is up to 35 mg/kg b.w.
the cytoreductive effect of hydroxycarbamide, particularly the drop of neutrophils,
Other known pharmacological effects of hydroxycarbamide which may contribute to its beneficial effects in Sickle Cell Syndrome include decrease of neutrophils,
renal impairment received hydroxycarbamide as a single dose of 15 mg/kg b.w. by using 200 mg,
At concentrations ranging from 10 to 300 µM, hydroxycarbamide does not stimulate the in vitro ATPase activity of recombinant human P glycoprotein(PGP), indicating that hydroxycarbamide is not a PGP substrate.
In the human, according to a retrospective analysis of a cohort of 123 adult patients treated with hydroxycarbamide, twenty-three pregnancies have been reported from 15 women treated with hydroxycarbamide
Because of the rarity of data on treatment with hydroxycarbamide in children less than 2 years of age,
The macrocytosis caused by hydroxycarbamide is not vitamin B12 or folic acid dependent.
However, hydroxycarbamide is presumed to be a transspecies carcinogen.