Voorbeelden van het gebruik van Multiple dosing in het Engels en hun vertalingen in het Nederlands
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Elimination The mean elimination half-life(t1/ 2) of bortezomib upon multiple dosing ranged from 40-193 hours.
The cartridges contain a total of 66 or 132 micrograms of interferon beta-1a and are designed for multiple dosing using an electronic injection device that delivers 8.8, 22 or 44 micrograms per dose. .
Upon multiple dosing, ritonavir accumulation is slightly less than predicted from a single dose due to a time
Because nevirapine induces its own metabolism with multiple dosing, this single dose study may not reflect the impact of hepatic impairment on multiple dose pharmacokinetics see section 4.4.
Similar CST½ values were observed following both single and repeated administration demonstrating that there is a predictable and consistent duration of action after multiple dosing of the sublingual tablet.
At a dose of 10 mg/kg, mean Vss averaged between 133(SD 24) ml/kg after multiple dosing, corresponding to a value of approximately 10 l for a 75 kg person.
to significant accumulation upon multiple dosing.
After multiple dosing with 750 mg every 8 hours for 28 days(steady-state),
accumulate more upon multiple dosing than does AsIII.
After multiple dosing, the highest concentrations are present in the adrenal glands,
Cmin of saquinavir in patients following multiple dosing of Invirase, saquinavir soft capsules,
of unboosted elvitegravir is~ 20% lower after multiple dosing versus a single dose, indicating modest autoinduction of its metabolism.
to approximately 25-30 hours following multiple dosing with 200-400 mg/ day.
the absence of auto- induction upon multiple dosing in patients indicates that cinacalcet is not an inducer of CYP3A4,
to 42- 64 ml/kg after multiple dosing(48-192 IU/kg), respectively.
Multiple dosing of 800/200 mg Kaletra once daily for 2 weeks without meal restriction(n=16) produced a mean±
slightly exceeding the exposure in humans after multiple dosing of 500 mg.
Multiple dosing of 800/200 mg lopinavir/ritonavir once daily for 2 weeks without meal restriction(n=16) produced a mean±
Patients with impaired liver function: after multiple dosing of ritonavir to healthy volunteers(500 mg twice daily)
Absorption: multiple dosing with 400/ 100 mg Kaletra twice daily for 3 to 4 weeks and without meal restriction produced a mean± SD lopinavir peak plasma concentration(Cmax) of 9.6± 4.4 μ g/ ml,