Although cannabis use precedes the onset of illness in most patients, there was no significant association between onset of illness and(cannabis use) that was not accounted for by demographic and clinical variables.
In most patients, the disorder is associated with contraction of a D4Z4 microsatellite repeat array on chromosome 4q, but this contraction can also occur in the absence of disease, so the underlying genetic mechanisms have remained elusive.
A previous phase 2 clinical trial of apalutamide for men with nonmetastatic, castration-resistant prostate cancer at high risk of progression showed that the drug was well tolerated and achieved responses in most patients.
Upon confirmation of the diagnosis is necessary to exercise adequate control of blood pressure and convulsions, and immediately stop the systemic administration of tacrolimus. In the case of the adoption of these measures, this condition is reversible in most patients.
A large single-institution series of 65 patients compared computed tomography(CT) scans in most patients(n= 54) with positron emission tomography(PET)-CT scans(n= 11).
Although the optimal duration of DAPT should take personal ischaemic and bleeding risks into account, this study suggested short term DAPT could be considered for most patients after PCI with DES, combining evidence from both direct and indirect comparisons.
The finding that most patients with LCH have BRAF and other RAS pathway mutations led to several reports of good responses to vemurafenib, a BRAF V600E inhibitor, in adult patients with LCH, Erdheim-Chester(ECD) disease, or mixed ECD/LCH, as well as in severe cutaneous LCH.
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