Objective response rate was similar whether patients were diagnosed with colorectal cancer(36%) or a different cancer type(46% across the 14 other cancer types).
Objective response rates did not differ significantly between the two arms(80% vs. 76%; p 0.2335), but osimertinib gave rise to a doubling of the duration of response 17.2 vs. 8.5 months.
The overall objective response rate was 20.5% for patients who were randomly assigned to treatment with topotecan and 13.2% for patients who were randomly assigned to treatment with paclitaxel(P= .138).
In addition to the overall response rate, the high complete response rate of 40% seen in this trial illustrates the potential of acalabrutinib to help patients.”.
With a response rate of over 50% in patients previously treated with immunotherapy, the data suggest treatment with erdafitinib may be preferential for patients with FGFR3 mutations.
臨床試験での奏効率は32.2%で、完全奏効が2.3%に得られ、部分奏効は約30%だった。
The overall response rate was 32.2%, including 2.3% of patients who experienced a complete response and almost 30% with a partial response..
The response rate was 27% in those with PD-L1 expression of at least 5%, 10% in those with PD-L1 expression of 1% to 5%, and 8% in those with PD-L1 expression of less than 1%.
In previously treated patients, the B-cell receptor-inhibitor ibrutinib was given to 94 symptomatic patients in two trials, with a response rate of 90% and a PFS of 69% to 86% in 18 to 24 months.
The efficacy analysis from Cohort A presented at ASCO GU showed a PSA response rate of 12 percent in the total cohort population(n=5/41), 14 percent among patients with measurable disease(n=4/28) and 8 percent(n=1/13) among patients with non-measurable disease.
The sustained complete clinical response rates at 12 months were 80% for PDT, 67% for placebo cream with red light, and 69% for treatment of physician choice(P= .04 for the comparison between PDT and the two combined physician-choice groups).
Response rates were low in both arms(10% for patients who received trabectedin vs. 7% for patients who received dacarbazine), but clinical benefit(that included both response rates and stable disease) was higher for the trabectedin group(34%) than for the dacarbazine group(19%).
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