DELOVANJEM JETER in English translation

• hepatic function
• liver function

Examples of using Delovanjem jeter in Slovenian and their translations into English

hude težave z delovanjem jeter(glejte poglavje 3, Kako jemati zdravilo Kalydeco).
severe problems with their liver function(please refer to section 3 on How to take Kalydeco).

so imeli preiskovanci z okvarjenim delovanjem jeter statistično značilna zmanjšanja izpostavljenosti dulaglutidu od 30% do 33% za povprečne vrednosti Cmax in AUC v primerjavi z zdravimi preiskovanci.
a clinical pharmacology study, where subjects with hepatic impairment had statistically significant decreases in dulaglutide exposure of up to 30% to 33% for mean Cmax and AUC, respectively, compared to healthy controls.

Poleg tega obrok aktivno pomaga pri reševanju težav z delovanjem jeter, koristno pa ga bo tudi za bolečine v sklepih, migrenah, srčnih boleznih,
In addition, the meal actively helps to solve problems with the functionality of the liver, it will be useful to take it also for pain in the joints,

študijo o učinkovitosti pri bolnikih z močno zmanjšanim delovanjem jeter.
a study on the effectiveness in patients with severely reduced kidney function.

Farmakokinetika trastuzumaba emtanzina in DM1 vsebujočih presnovkov je bila ocenjena po dajanju 3,6 mg trastuzumaba emtanzina na kg telesne mase bolnikom s HER2+ metastatskim rakom dojk z normalnim delovanjem jeter(n= 10), blago(razred
The pharmacokinetics of trastuzumab emtansine and DM1-containing catabolites were evaluated after the administration of 3.6 mg/kg of trastuzumab emtansine to metastatic HER2+ breast cancer patients with normal hepatic function(n=10), mild(Child-Pugh A;

V primerjavi z zdravimi osebami z normalnim delovanjem jeter je bila povprečna vrednost AUC simeprevirja v stanju dinamičnega ravnovesja 2,4-krat večja pri osebah brez okužbe s HCV, ki so imele zmerno
Compared to healthy subjects with normal hepatic function, the mean steady-state AUC of simeprevir was 2.4-fold higher in non-HCV infected subjects with moderate hepatic impairment(Child-Pugh class B)

bolniki z okvarjenim delovanjem jeter, diabetično ketoacidozo(resen zaplet, ki se lahko pojavi pri sladkorni bolezni)
those with reduced liver function, diabetic ketoacidosis(a serious condition that can occur in diabetes),

V primerjavi z osebami z normalnim delovanjem jeter je bila sistemska izpostavljenost po enkratnem odmerku aksitiniba pri osebah z blago okvaro jeter(razred A po Child-Pughu)
Compared to subjects with normal hepatic function, systemic exposure following a single dose of axitinib was similar in subjects with mild hepatic impairment(Child-Pugh class A)

V sedmi študiji so bolnike s cirozo jeter in stabilnim delovanjem jeter(kompenzirano cirozo),
In a seventh study, patients with liver scarring but stable liver function(compensated cirrhosis)

ritonavirja in 38% večjo C12 ritonavirja kot osebe z normalnim delovanjem jeter, ki so dobile standardno shemo fosamprenavirja z ritonavirjem 700 mg/ 100 mg dvakrat na dan.
38% higher ritonavir C12 than achieved in subjects with normal hepatic function receiving the standard fosamprenavir with ritonavir 700 mg/ 100 mg twice daily regimen.

za 39% v primerjavi z osebami z normalnim delovanjem jeter.
as compared to subjects with normal liver function.

telesni masi primerljivih zdravih odraslih osebah z normalnim delovanjem jeter(n=19).
hepatic impairment and in age-,sex-, and weight-matched healthy adults with normal hepatic function(n=19).

ni bil klinično pomembno drugačen kot pri zdravih prostovoljcih z normalnim delovanjem jeter.
not clinically significantly different than in healthy volunteers with normal hepatic function.

23% oz. 48% v primerjavi z osebami z normalnim delovanjem jeter.
48%, respectively, compared to subjects with normal hepatic function.

njegovih presnovkov nista pomembneje spremenili v primerjavi z osebami z normalnim delovanjem jeter.
its metabolites did not change significantly compared to subjects with normal hepatic function.

na farmakokinetiko posakonazola kaže na povečanje plazemske izpostavljenosti temu zdravilu v primerjavi s preiskovanci z normalnim delovanjem jeter, vendar ne nakazuje, da bi bilo treba prilagoditi odmerek(glejte poglavji 4.4 in 5.2).
on the pharmacokinetics of posaconazole demonstrate an increase in plasma exposure compared to subjects with normal hepatic function, but do not suggest that dose adjustment is necessary(see sections 4.4 and 5.2).

njegovih presnovkov nista pomembneje spremenili v primerjavi z osebami z normalnim delovanjem jeter.
its metabolites did not change significantly compared to subjects with normal hepatic function.

v primerjavi z bolniki z normalnim delovanjem jeter(skupni bilirubin in AST ≤ ZMN; n= 804).
n= 92) compared to patients with normal hepatic function(total bilirubin and AST≤ ULN; n= 804) in the population PK analyses.

Vpliva zmerno okvarjenega delovanja ledvic(razred B po klasifikaciji Child-Pugh) na farmakokinetiko bosentana in njegov primarni presnovek Ro 48-5033 so raziskali v študiji, v katero je bilo vključenih 5 bolnikov s pljučno hipertenzijo, povezano s portalno hipertenzijo in okvarjenim delovanjem jeter razreda B po klasifikaciji Child-Pugh, in 3 bolniki s pljučno arterijsko hipertenzijo zaradi drugih razlogov in normalnim delovanjem jeter.
The impact of moderately impaired liver function(Child-Pugh class B) on the pharmacokinetics of bosentan and its primary metabolite Ro 48-5033 was investigated in a study including 5 patients with pulmonary hypertension associated with portal hypertension and Child-Pugh class B hepatic impairment, and 3 patients with pulmonary arterial hypertension from other causes and normal liver function.

po uporabi 800 mg enkrat na dan sta podobni medianama pri bolnikih z normalnim delovanjem jeter(glejte preglednico 7).
after administration of 800 mg once daily are similar to the median in patients with normal hepatic function(see Table 7).