Research on dose dependence of non-oncologic diseases of the thyroid gland for inhabitants of the Kaluzhsk region, exposed to radionuclide iodine in their childhood due to the Chernobyl accident.
Our results suggest that management of thyroid screening for schoolchildren at ordinary times may be beneficial for monitoring the adverse effects of radioactive iodine from the standpoint of future prospective study.
This application was mainly based on the results of the SELECT Study(Study 303)1 conducted globally for patients with radioactive iodine-refractory differentiated thyroid cancer.
Although several studies independently estimated dose- response relationships between radioiodine and thyroid cancer incidence in Chernobyl, 16- 18 precise doses for cumulative radiation have not yet been established.
A radioactive iodine scan(RAI scan) is done to find areas in the body where thyroid cancer cells that were not removed during surgery may be dividing quickly.
Based on the provisional regulation value under the Food Sanitation Act, samples of which the radioactive iodine concentration was 300 Bq/kg or more were determined to be in excess of reference value.
Following Chernobyl, the amount of radioactive iodine in the thyroid glands of 110,000 children and 40,000 adults was measured and a cancer registry was created.
Sorafenib is a kinase inhibitor drug approved for the treatment of primary kidney cancer(advanced renal cell carcinoma), advanced primary liver cancer(hepatocellular carcinoma), and radioactive iodine resistant advanced thyroid carcinoma.
As for the thyroid exposure due to the intake of radioactive Iodine-131, we intend to use a different method from that used for external exposure and this will be investigated in research that is separate from the research sponsored by the Ministry of the Environment.
Success rates were similar between the two radiation doses and the two thyrotropin-stimulation methods, leading the researchers to conclude that the use of human thyrotropin and low-dose radioiodine may be sufficient for managing low-risk thyroid cancer.
After the nuclear accident at Fukushima Nuclear Power Plant No.1 belonging to Tokyo Electric Power Co., a radioactive iodine level measured at a water treatment facility in Tokyo was 210 becquerels(Bq) per kilogram(kg), well over the interim legal safety limits for infants(100 Bq per kg) current at the time. After it was reported that the Tokyo Metropolitan Government urged residents not to give tap water to babies, bottled water quickly disappeared from store shelves.
Apart from the people exposed to high levels of radioactive iodine mentioned above, only those liquidators who worked around the stricken reactor in the first two years after the accident(240 000), the evacuees(116 000), some of whom received doses well in excess of 100 mSv, and the residents of the highly contaminated SCZs(270 000), received doses significantly above typical natural background levels.
放射性ヨウ素療法。
Radioactive iodine therapy.
RAI=放射性ヨウ素;。
RAI= radioactive iodine;
放射性ヨウ素131。
Radioactive Iodine 131.
甲状腺照射または放射性ヨウ素治療。
Thyroid irradiation or radioactive iodine treatment.
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