Voorbeelden van het gebruik van Tolerated dose in het Engels en hun vertalingen in het Nederlands
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A maximum tolerated dose has not been determined in patients
The recommended daily dose of 12.5 mg/kg body weight corresponds to the Maximum Tolerated Dose MTD.
Cyramza has been administered in a Phase 1 study up to 10 mg/kg every two weeks without reaching a maximum tolerated dose.
In case of mild toxicity, the dose should be reduced until the maximum tolerated dose is attained.
Carcinogenic effects only at very high dose levels exceeding the'maximal tolerated dose.
achieve the maximum possible efficacy in these patients the dose should normally be continued at the highest tolerated dose.
It is used in patients whose disease is insufficiently controlled with the maximum tolerated dose of metformin taken alone
rats at the maximum tolerated dose, although the exposure to rivastigmine
For patients inadequately controlled on dual therapy with pioglitazone and a maximally tolerated dose of metformin, the dose of metformin should be maintained,
Carcinogenicity No carcinogenicity was noted in mice at the maximum tolerated dose, which corresponded to a systemic exposure approximately 2 to 3 times higher than the clinical exposure.
These changes were not considered to be clinically meaningful as the maximum tolerated dose(4-6 mg/m2)
the maximum tolerated dose(MTD) was 1,000 mg/m2 per cycle both in children and in adults.
exercise plus maximal tolerated dose of a sulphonylurea alone do not provide adequate glycaemic control
Patients were titrated over four weeks to a target dose of 8 mg per day or the highest tolerated dose and treated for an additional 13 weeks on the last dose level achieved at the end of the titration period.
Current smokers, pharmacokinetic analyses at steady-state indicated a dose proportional increase in erlotinib exposure when the Tarceva dose was increased from 150 mg to the maximum tolerated dose of 300 mg.
an intrathecal dose of 35 mg was identified as the maximum tolerated dose.
to a maximum tolerated dose within the recommended optimal weight-adjusted dose range based upon clinical judgement of response
exercise plus maximal tolerated dose of a sulphonylurea alone do not provide adequate glycaemic control
The present ADI of 25 mg/kg b.w. is based on the no-adverse effect level in the longterm rat studies in which, however, the maximum tolerated dose has not been reached.
It is used in patients whose disease is insufficiently controlled with the maximum tolerated dose of metformin taken alone